Three steps to use Prophet:

• Input the corresponding values for demographic and clinical biomarkers (Age, Smoke, Stage, Sex);
• Click "Edit score" to input the corresponding values for epigenetic and transcriptional biomarkers;
• Wait a few seconds, then see the predictions in the interactive KM plot.

Data sources:

• TCGA cohort: https://xenabrowser.net/
• GEO cohorts: https://www.ncbi.nlm.nih.gov/geo/

If you use Prophet in your work, please cite:

• Zhang R#,*, Chen C#, Dong X#, Shen S, Lai L, He J, You D, Lin L, Zhu Y, Huang H, Chen J, Wei L, Chen X, Li Y, Guo Y, Duan W, Liu L, Su L, Shafer A, Fleischer T, Bjaanæs MM, Karlsson A, Planck M, Wang R, Staaf J, Helland Å, Esteller M, Wei Y*, Chen F*, Christiani DC. Independent validation of early-stage non-small cell lung cancer prognostic scores incorporating epigenetic and transcriptional biomarkers with gene-gene interactions and main effects. Chest. 2020 Aug; 158 (2): 808-819.

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